Creative Nano is thrilled to announce a significant milestone achieved within the BIOMAC Project, marking a major advancement in the scale-up of our pilot line for lignin nanoparticle (LNP) production.
After over 4.5 years of collaborative effort, the BIOMAC project, focused on building a robust Open Innovation Test Bed (OITB) for sustainable bio-based nanomaterials, has reached its culmination with multiple breakthroughs.
Creative Nano has led the design and validation of a semi-industrial ultrasonic-assisted process (Pilot Line 4) capable of producing kilogram-scale quantities of lignin nanoparticles daily using only water as solvent, a clear step forward in sustainable materials production.
Key achievements include:
- Successful deployment of the ultrasound-assisted reactor system within CNano’s upgraded pilot line, achieving consistent control of particle size and dispersity through real-time monitoring and freeze-drying protocols.
- Filing of a patent (EP4471093) based on the ultrasonication method developed for LNP synthesis.
- Publication of a CEN Workshop Agreement (CWA) standardising the ultrasound-based method to ensure reproducibility and scalability across laboratories and industry settings.
Moreover, CNano demonstrated the functional properties of these LNPs for real-world applications, such as enhanced barrier, antioxidant, and antimicrobial performance in food packaging, controlled-release properties for fertilisers and mulch films in agriculture, and biocompatible carriers for cosmetics and therapeutics.
The culmination of the BIOMAC journey is a testament to strong collaboration: between research institutions, regulatory standardisation bodies, and industrial partners. The successful achievements of Creative Nano and the pilot line place the technology firmly on the path to commercialisation and regulatory alignment.

